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From the always-enjoyable Urban Dictionary:

Ho (n): 1) One rung below whore on the social ladder. We don't love dem hoes! 2) The laugh Santa Clause says during Christmas time. Ho ho ho ho merry X-mas! 3)Anyone who dehumanizes themselves by selling their soul to others. The term can be applied to either a man or a woman or—as in the case of Anne Coulter—both.

Anne Coulter: You two ladies look awfully interesting. Are you Indians?
Woman #1: Yes, I'm a Navajo.
Woman #2: I'm an Arapahoe.
Anne Coulter: What a coincidence! I'm a right-wing ho!
 —NH

Urban Dictionary