The Children's Hospital of Michigan in Detroit reports 21-month-old Madeline Reid has died of the rare respiratory virus that, in the past two months, has infected hundreds of children across the country.

Children's Hospital of Michigan's chief medical officer, Dr. Rudolph Valentini, released a statement saying the Centers for Disease Control and Prevention confirmed Madeline's case when she arrived at the hospital. Valentini continued:

"It is never easy to lose a child, and our entire health care team at the Children's Hospital of Michigan is deeply saddened by this family's loss and mourns with them during this very difficult time."

She passed away Friday afternoon.

According to the CDC, five people infected with the virus have died, including a four-year-old boy from New Jersey, though it's not yet clear what role the virus played in their deaths. The CDC reports 691 people in 46 states and Washington, D.C. have been infected so far.

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