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While most people on Wall Street are in a state of panic these days, it's worth noting that not everyone is heading into Christmas vacation with their gloomy look on their faces. Financial News has issued its list of the year's biggest winners and losers. The man who earned the No. 1 spot on the "Profit Makers" list? John Paulson, the gloomy-looking hedge fund manager on your left, who not only took home a ridiculous $3.7 billion last year, but is up another 20 percent in 2008. [WSJ]