Daily Show Don Juan, Wyatt Cenac, explains to a comedy-club audience that his "dick and balls are pretty open-minded when it comes to religion..." Whether it's political satire, or just talking about Jewish princesses, Wyatt is a smooth comedic operator.

Japanese pranks are great for their over-the-top elaborateness, attention to detail, and cruelty. Today, we have eight of our favorite practical (and not-so-practical) jokes, straight from the Land of the Rising Sun. Tanoshimasu!

During an interview segment with Fred Willard on Late Night with Jimmy Fallon this evening, things got pretty awkward for a second when it appeared as though Fallon took a dig at his predecessor, Late Show host David Letterman.

Well, it took a mere 4 days before The Fiesta Bowl handed us the first instant classic of 2010. Without further ado, here is Cowbell Girl.

Snooki took some time from her busy bar-hopping tour tonight to stop by The Jay Leno Show (via satellite) and participate in the 10@10 segment. Her New Year's Eve hotel debacle, Bumpits, pickles, Twilight, Sinatra and more—ahead!

The man in the white suit could bring a crowds to tears with laughter, unlike the man in the latest Pink Panther movie. Watch as the Steve Martin we all actually love gives a new face to venereal disease.

Before the Herzhog re-imagining was upon us, with it's surprisingly successful casting of Nicholas Cage, the 1992 Bad Lieutenant with Harvey Keitel was all we had... or was it? Bill Hader of SNL gave his own interpretation of the role.

On Family Guy, Peter had amnesia after being knocked unconscious by Richard Dawson while on Family Feud. He then had to relearn how to do everything, including drive. Lois' advice? Play Grand Theft Auto for eight hours.

He's a mainstay on NBC's The Office, a star of The Hangover, and it shouldn't surprise anyone that he's a skilled stand-up comic. Ed Helms played a virtuoso set at 2009's Telluride Comedy Festival complete with a baby grand piano.

Richard Pryor as a blind man, Gene Wilder as a deaf man, hijinx, bumbling, spills, chills and thrills? What more could you want in a comedy?

Say what you want about John Mayer, he's actually a decent stand-up comedian. In this clip, he riffs on masturbation and US Weekly on a boat full of people we're assuming are screaming girls.

Back in the day, The State pulled off a pitch perfect basketball shoe commercial parody, very reminiscent of the BK Dymacel commercials. If you don't remember, then the 90s are in fact "back in the day" for you.

Every comedy nerd should be familiar with, improv king, Sean Conroy. Not only can he make up hilarious scenes and characters on the spot, he can also write good stand up material. Here he talks about his quarrels with wishing.

Daniel Tosh is hilariously unapologetic. In this video, he riffs about his hate for the midwest and his plan to fight homelessness. He's one of the only comedians today that goes after the things that people are afraid to say.

Dwanye Perkins is 100% relatable which makes him 100% funny. In this clip he talks about how shitty being "the friend you don't like that way" is.

From David Cronenberg's Cabbage Patch Kids to Wes Anderson's Teddy Ruxpin, these movie trailers make wishes come true.

There are a few TV shows where the stupidity of the American people is featured regularly—Maury is one example; the fourth hour of Today, another. Occasionally, Wheel of Fortune provides us with such moments, and yesterday's show delivered.

Nick Thune is one of the better stand up musicians working today. In this clip he takes us through his experience posting a "missed connection" entry on Craigslist.


[viaYouTube

Despite the fact that we're partial to Apple products in general, this spoof is spot-on and hilarious. Lyrics like "a Nano in pink? anything is possible?" and "if you're on a PC then you're not CEO!" put us in stitches.

Watch as the ever popular British comedian, Ricky Gervais, dissects some of the most well known nursery rhymes and shows us how absurd and morbid they really are.